Coffees Java Genes Doesn’t Buzz Everyone?


Coffee’s Java Genes  Doesn’t Buzz Everyone?



[1]: Coffees Java Genes  Doesn’t Buzz Everyone?  Many studies that investigated coffee behavior found the brew doesn’t affect everyone the same. While there’s indeed such a thing as a caffeine tolerance, some people simply can’t get wired with coffee.



Coffees Java Genes  Doesn’t Buzz Everyone?  Conversely, other people stay awake the whole night if they have a single cup of joe before bed time. Now, a new study has identified a set of genes involved in metabolizing coffee which explains why not everyone reacts to the drink equally — and this might actually have clinical implications.

Coffees Java Genes  Doesn’t Buzz Everyone?  The study was led by Marilyn Cornelis, assistant professor in the department of Preventive Medicine at Northwestern University Feinberg School of Medicine. Cornelis previously identified gene variants which were associated with enjoying coffee more.

Coffees Java Genes  Doesn’t Buzz Everyone?  This time, Cornelis and colleagues sampled the blood of participants who had drunk coffee earlier and studied their metabolites — intermediate products of metabolic reactions catalyzed by various enzymes that naturally occur within cells.

The fewer metabolites you have in your blood, the faster your caffeine metabolism is.

“Each of us could be potentially responding to caffeine differently, and it’s possible that those differences can extend beyond that of caffeine,” Cornelis said.

Coffees Java Genes  Doesn’t Buzz Everyone?  By cross-screening these caffeine metabolites with the genetic makeup of each participant, the researchers were able to identify a set of genes involved in metabolizing coffee.

Among them were gene variants which were previously associated with coffee-related behavior, but also a few new ones.

One gene called CYP2A6 was previously linked to smoking behavior and nicotine metabolism — now it’s related to caffeine metabolism as well. Another gene called GCKR was previously repeatedly linked to glucose and lipid metabolism in independent studies.

Coffees Java Genes Doesn’t Buzz Everyone?  New genes that metabolize caffeine also coded for proteins involved in metabolizing important drugs, like those used to treat insomnia, Parkinson’s disease, and more.

It’s not clear how important this is, but this is not the first time the metabolization of caffeine, nicotine, and other drugs seem to overlap.

“This makes sense, conceptually, but the genetic research confirms it and further re-emphasizes the notion that not everyone responds to a single cup of coffee (or other caffeinated beverage) in the same way,” Cornelis said.

“It’s important to know, given coffee has been implicated in so many diseases.”


 

Six new variants via coffee consumption.

[2]: Your daily desire for that morning latte may run as deep as your genes, according to a large-scale study that finds six new variants associated with habitual coffee use.

A genome-wide analysis of more than 120,000 coffee drinkers of European and African-American ancestry — including data from the Women’s Health Initiative coordinated by the Fred Hutchinson Cancer Research Center – shows that genetic factors may fuel individual preference for the drink, as well as the way that jolt of java impacts the body and behavior. Those new genetic markers were associated with people who drink more coffee, the study found.

“This suggests that genes may influence your preferences for coffee and there may be biological underpinnings for habitual coffee consumption,” said Dr. Marian Neuhouser, a nutritional epidemiologist with Fred Hutch’s Public Health Sciences Division.

Neuhouser and Dr. Ulrike “Riki” Peters were among more than 100 scientists from 116 institutions participating in the Coffee and Caffeine Genetics Consortium effort to conduct a genome-wide meta-analysis, the largest such study to date. The paper was published Tuesday in the journal Molecular Psychiatry.

Previous research led by primary study author Dr. Marilyn Cornelis, a research associate in the department of nutrition at the Harvard School of Public Health, had identified two loci, or genetic variants, found in people who drank the most coffee.

The new work quadruples the number of identified genetic variants linked to regular coffee use. In addition to two previously discovered variants, AHR and CYPIA2, the study discovered variants POR and ABCG2, which map to genes involved in caffeine metabolism, or the speed with which the body processes the stimulant drug.

Two other variants were discovered near genes BDNF and SLC6A4 that may influence the pleasurable or rewarding effects of caffeine, the study found. And two other variants, near genes GCKR and MLXIPL, which are involved in metabolism of glucose and lipids, had not previously been associated with the effects of coffee.

That’s all a technical way of saying the scientists think they’ve found new explanations for why so many people need a regular coffee fix. In the U.S. alone, more than 60 percent of adults consume coffee daily, according to the National Coffee Association.

“Lo and behold, it showed that the caffeine component is what’s driving our consumption,” said Cornelis, who has been working on the new paper since the last one was published in 2011.

It’s crucial to have a large enough sample to ensure that the findings are robust, said Cornelis. That’s why she relied on data from such a large number of researchers, including many who collected the coffee consumption information as part of other population-based studies of nutrition and disease.

In the case of Fred Hutch, Neuhouser and Peters provided data from the Women’s Health Initiative that included nutritional surveys with coffee consumption information from nearly 8,000 African-American coffee drinkers. Such data helped provide a perspective that was previously missing, Cornelis said.

More research is needed to learn the precise roles of the new genetic variants and what they might mean for individual response to coffee. Coffee has been linked to several health benefits, including a lower risk of Parkinson’s disease and Alzheimer’s disease, with possible effects on lower blood pressure and decreased rates of problems such as depression and stroke.

“Our findings may allow us to identify subgroups of people most likely to benefit from increasing or decreasing coffee consumption for optimal health,” Cornelis said.


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